Lee JT, Paquette R, Sercarz JA, Wang MB. Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17, 27, 40]. Feinberg SM, Ou SH, Gu M, Shibuya TY. Arch Pathol Lab Med. What does prominent lymphoid tissue at base of tongue on an MRI report mean. Indian J Cancer. Three reactive samples, either tonsils or lymph nodes, were included to establish cut-off values. Five cases of severe HBT were detected among 306 patients submitted to videolaryngoscopy over a period of 2 years, corresponding to 1.6% (5/306) of the total sample studied. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. St. Louis, MO: Elsevier; 2016. The patient was decannulated and discharged home 14 days after tracheotomy. Although it had been described in the literature, occurrence within oral cavity is rare. Federal government websites often end in .gov or .mil. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. 1998;112:9914. Carcinomas of the base of the tongue: diagnosis using double-contrast radiography of the pharynx. https://doi.org/10.1002/ajh.23176. Virchows Arch. 2007;86:35660. 4, pp. volume15, Articlenumber:30 (2020) The https:// ensures that you are connecting to the 353358, 2001. Rinsho Ketsueki. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. The tumour cells were large and blastic, with a high mitotic rate, which was similar to diffuse large B lymphoma tumour cells. Generally, MCL patients have a median age of 60years and a striking male predominance [42] .Three of the four cases of MCL including our case, occurred at the base of the tongue. Bone marrow biopsy is necessary to rule out CNS involvement. HHS Vulnerability Disclosure, Help 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. Before HHS Vulnerability Disclosure, Help The clinical features of tongue base involvement by NHL are not specific [17]. The case of DLBCL showing HPV DNA positivity (case 6). 2006;17:143440. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. Clipboard, Search History, and several other advanced features are temporarily unavailable. Nathu RM, Mendenhall NP, Almasri NM, Lynch JW. M Gromet, M J Homer, B L Carter Published Online: Sep 1 1982 https://doi.org/10.1148/radiology.144.4.7111732 PDF Share Article History Published in print: 1982 Figures References Related Details Vol. In the literature, findings of RLH are well-documented. What is the treatment for reactive lymphoid hyperplasia? Tracheotomy was performed to relieve respiratory oppression. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. 2001;94:1536. During the follow up period, the MCL patient and an elderly DLBCL patient died. Discussions concentrating on NHL of the base of the tongue have focused on the histopathology and lack details regarding progress in the treatment response and prognosis. Semin Oncol. The tissue demonstrates a polarized mantle zone beneath a somewhat attenuated epithelium. PubMed Two patients survived more than six years. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Please enable it to take advantage of the complete set of features! Ear Nose Throat J. Cancer at the base of the tongue is usually diagnosed at an advanced stage, when the tumor is larger and the cancer has spread into the lymph nodes in the neck. In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). MeSH PubMed Lopez-Guillermo et al. Our HPV-infected patient indeed had a favourable prognosis, and he was alive and free of disease when this manuscript was prepared (68months). 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. Had biopsy on axillary lymph node. CD30 antibodies were purchased from Maixin Biotech. Mitosis could be observed easily. Am J Hematol. 2017;58:203342. [2], Follicular hyperplasia is a stimulation of the B cell compartment. Google Scholar. Unable to load your collection due to an error, Unable to load your delegates due to an error. She can be contacted at nburkhart@tamhsc.edu. This report adds valuable knowledge to the possible virus infection status of tongue NHL, due to its rare occurrence. This entity was first described in 1973 by Adkins. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. The tongue has a rich network of lymphatics that drain to neck levels I-III, which is the usual pattern of spread when these tumors metastasize. 5760, 1993. As they mount an immune response, lymphoid cells can proliferate and enlarge. 2009 Sep;114(6):948-59. doi: 10.1007/s11547-009-0416-4. Never disregard or delay professional medical advice in person because of anything on HealthTap. Ann Diagn Pathol. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. National Library of Medicine Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. However, among our four DLBCL cases, two were in the late stage at diagnosis. Head Neck. Of the DLBCL patients, 4 were not otherwise specified lymphomas (NOS) and 1 was T cell/histiocyte rich large B-cell lymphoma. Spontaneous regression has also been reported. ENT manifestations of gastroesophageal reflux. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Zhiyong Liang or Beverly Wang. Radiology. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. ZL, BW, XR and YC reviewed all the cases together. Careers. In special cases, several biopsies are needed. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Cancer. https://doi.org/10.1016/j.anndiagpath.2005.09.020. Epub 2016 Sep 17. Six of the cases exhibited tongue base masses with smooth surface membranes. Mamede RC, Amaral Fd, Raimundo DG, Freitas LC, Ricz HM, Mello Filho FV. Rasmussen PK. HIV serology was negative. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. Part of All 7 lymphomas were localized at the base of the tongue. In the middle power view, there were plenty of moderate to large cells with distorted nuclear contours (Fig. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. She was awarded the Dental Professional of the Year in 2017 through the International Pemphigus and Pemphigoid Foundation and is a 2017 Sunstar/RDH Award of Distinction recipient. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. Immunohistochemistry was negative for lymphoma. Clinicopathological information including age, gender, tumour location, histological subtype, grading, staging, survival, and response to treatment was acquired from the archives. Imaging and pathological findings of DLBCL (case 5). On this Wikipedia the language links are at the top of the page across from the article title. Bookshelf 2000;113:5128. With proper therapy, even late stage tongue base lymphomas can be suppressed and remain in remission. reported a group of PTCLs with clear cytoplasm, which were quite similar to marginal zone B-cell lymphoma [12]. D. L. Harsany, J. Ross, and W. E. Fee, Follicular lymphoid hyperplasia of the hard palate simulating lymphoma, OtolaryngologyHead and Neck Surgery, vol. Her IPI score was 3 (high risk group). Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. 4). 2005;23:2797804. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. PET-CT/CT/MRI scans of the cancerous areas were reviewed to assess the extension of the lesions, including to the bone and thorax. showed that 74% of DLBCL cases have P16 methylation and a relatively old age [32]. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. statement and government site. f. Tumour cells were negative for CD5 (200 x). Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. J Natl Cancer Inst. Dysphagia. d. Tumour cells were positive for CD5 (200x). https://doi.org/10.22034/APJCP.2017.18.10.2781. 4, pp. Some cases of DLBCL may be associated with HPV infection. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. 1987;149:57581. The airway was subsequently secured, and the procedure was undertaken. Vocal cord involvement can cause choking. When we think of lymphoid hyperplasia in the oral cavity, we often think of localized increases of lymph node tissue. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. The prognosis for MCL seems to be poorer than that for DLBCL at the base of the tongue. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. The site is secure. Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. Am J Surg Pathol. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. 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